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Vine VC

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VCMatch tracks Vine VC as an investor focused on Healthtech, Biotech, and Medtech companies, Pre-Seed and Seed rounds, Canada, United States, and North America markets, and $625k to $20m check sizes. Upload your deck to compare your startup against the full private matching profile.

Check Size

$625k to $20m

Focus Areas

Healthtech, Biotech, Medtech

Geography

Canada, United States, and North America

Investment Thesis

Vine Ventures was founded to address the global mental health crisis by driving the emergence of innovative solutions for mental health and wellbeing. The firm is rethinking venture capital for a novel approach to health and wellness, with a core belief that ‘the two most pressing problems facing humanity are mental health and aging.’ They emphasize investing in ‘constructive not extractive capital’ and seek to create an ethical industry rather than extractive business models. The firm operates smaller funds with niche focus where managers can comprehensively survey their markets, identify outlier founders, and provide contextually valuable support.

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Investment Focus

Who should take a closer look

Vine VC is most relevant for founders raising Pre-Seed, Seed, and Series A rounds in Healthtech, Biotech, Medtech, and Digital Health, especially across Canada, United States, and North America, with public check-size signals around $625k to $20m.

Focus statement

Vine invests across three interconnected domains: psychedelics (novel approaches to conscious health & wellness), neurotechnology (brain mapping, neuromodulation, BCIs), and longevity (therapies targeting hallmarks of aging). They target early-stage companies seeking to advance novel modalities for mental health and wellbeing, with particular interest in entrepreneurs and builders working on projects with significant impact potential.

Value Add

  • Reciprocity pledge: 50% of GP profits are donated back to the mental health community, scaling from 20% at 2x DPI to 50% at 5x DPI
  • Deep market expertise across three interconnected domains (psychedelics, neurotechnology, longevity) with tracking of ~1,000 psychedelic companies and 300+ longevity companies
  • Preference for 'cash flow positive, default alive positions' alongside high-conviction bets, favoring businesses with positive unit economics
  • Focus on 'high-integrity teams' and ethical approaches to avoid dystopian futures of expensive, sterile treatments with no community connection
  • Portfolio includes representative companies addressing the middle of the value chain where more value accrues than venture capital deployed

Stage And Sector Fit

Portfolio Highlights

Othership

Mental Health Wellness

Bright Minds Bio

Psychedelics Biotech

Gilgamesh Pharmaceutical

Psychedelics Biotech

Psygen

Psychedelics Biotech

Bexson Biomedical

Neurotechnology

Tripp

Mental Health Wellness

Tessera

Psychedelics Biotech

Alto Neuroscience

Neurotechnology

+ 21 more companies in their portfolio

Investment Team

3 Partners at Vine VC

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