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SmartGateVC

smartgate.vc

SmartGateVC pioneers AI-driven frontiers in Brain-Computer Interfaces (BCI), Life Sciences, Physical World applications, and Cybersecurity. They operate across Southern California, the wider U.S., and Armenia with a $50K-$1M ticket size at pre-seed and seed stages.

Check Size

$50K - $1M

Focus Areas

Ai Ml, Biotech, Medtech

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Investment Thesis

SmartGateVC invests at the intersection of science and entrepreneurship to disrupt the status quo. They identify industry-defining ideas early (pre-seed to seed stage) and inject capital, talent, and industry connections to power their transformation. The firm believes that future tech giants emerging at the intersection of AI and life sciences will have deep roots in fundamental IP and wet lab capabilities. They emphasize backing ‘hero teams’ - capable, unstoppable, and unbreakable founders - and take a hands-on approach beyond capital deployment.

What Sets Them Apart

  • Operates dedicated tech hubs (Hero House) in California and Armenia serving as physical innovation centers
  • Provides integrated support ecosystem including affiliated ML Lab for solving scientific challenges, Angel Network, Mentor Network, and legal/IP/tax support
  • Strong track record: 33 portfolio companies since 2018 with $6.5M raised for every $100K invested, with 16 companies progressing to Seed, Series A, and Series B
  • Bridges science and entrepreneurship with founders often having PhD backgrounds or deep technical expertise
  • Focuses on technology transfer and lab-to-market guidance for scientist-founders
  • Top-tier follow-on investor support from firms like NVIDIA, Y Combinator, Mosaic Ventures, and others
  • Geographic arbitrage advantage with Armenian tech hub providing cost-efficient R&D capabilities

Portfolio Highlights

SuperAnnotate

Ai Ml

Deep Origin

Life Sciences

ThirdLaw Molecular

Life Sciences

Britive

Cybersecurity

ActiveLoop

Ai Ml

Grovf

Infrastructure

Krisp

Ai Ml

Podcastle

Ai Ml

+ 16 more companies in their portfolio

Investment Team

10 Partners at SmartGateVC

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