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GreyMatter Capital

greymattercapital.com

GreyMatter invests in mental health and brain health companies across clinical care delivery, therapeutics, technology platforms, and support services. They focus on supporting bold founders reshaping the future of mental health through a comprehensive support model.

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Investment Thesis

GreyMatter believes mental health represents one of humanity’s most significant challenges and greatest opportunities. They view this as a multi-decade transformation where breakthrough innovation can go from concept to impacting millions of lives rapidly. The firm takes a systems change approach, recognizing that despite dramatic improvements in human lifespan and GDP since 1960, mental health and wellbeing have declined, with one in five Americans having mental illness and limited treatment access. They aim to reverse this decline by creating collaborative infrastructure across research, payors, providers, policy, and technology—sectors that have been historically siloed.

What Sets Them Apart

  • Hands-on founder support at every stage of the journey, not just capital provision
  • Deep multidisciplinary network spanning clinical practice, scientific research, government policy, regulatory compliance, and commercialization
  • Access to playbooks and data from successful mental health founders to shape strategy
  • Direct introductions to customers across healthcare industry (health plans, employers, health systems, schools)
  • Support with critical hires and executive team building
  • Specialized guidance and coaching through startup turbulence
  • Founded by operators with direct mental health startup exit experience (Genoa Telepsychiatry acquired by Optum)

Portfolio Highlights

Anna Health

Behavioral Health

Applied Cognition

Neurology Therapeutics

Blackbird

Behavioral Health

Brevy

Behavioral Health

Coral Care

Behavioral Health

Era

Substance Use Disorder

FamilyWell

Behavioral Health

Finni

Behavioral Health

+ 23 more companies in their portfolio

Investment Team

4 Partners at GreyMatter Capital

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